COPD – GSK 300631

Patient and caregiver smiling

COPD Research Study

The study primarily aims to demonstrate the superiority of GSK5784283 as an add-on therapy compared to placebo in reducing the annualized rate of moderate and severe chronic obstructive pulmonary disease (COPD) exacerbations.

A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study of the Efficacy and Safety of GSK5784283 (Felcorekibart) in Participants 40 to 80 Years of Age With Moderate to Very Severe COPD (PERSIST COPD-2)

Inclusion Criteria:

  • Male or eligible female participants.
  • Participants with >=40 to less than or equal to (<=) 80 years of age.
  • An eosinophilic phenotype with elevated BEC.
  • Moderate to very severe COPD with frequent exacerbations.
  • Participants with elevated COPD assessment test (CAT) score.
  • Current or former cigarette smokers.
  • On triple (Inhaled corticosteroid [ICS]+ Long-acting muscarinic antagonist [LAMA]+ Long-acting beta-agonist [LABA]) or dual inhaled COPD therapy, if ICS is considered not appropriate.

Exclusion Criteria:

  • Current or prior physician diagnosis of asthma.
  • Other clinically significant lung disease.
  • Pneumonia, COPD exacerbation, or lower respiratory tract infection within the 4 weeks prior to Screening Visit 1.
  • Participants with a history of, or plan for lung volume reduction surgery / endobronchial valve procedure.
  • Continuous oxygen therapy (more than 16 hours/ day).
  • Cor pulmonale resulting in right heart failure and severe pulmonary hypertension.
  • A current malignancy or history of malignant neoplasm within the last 5 years (except definitively treated non-melanoma skin cancer or carcinoma in situ of the uterine cervix).
  • Myocardial infarction, unstable angina or stroke within 6 months of screening, unstable arrhythmia.
  • New York Heart Association class III or IV heart failure.
  • Other significant medical conditions that could impact participants’ safety or study outcomes.

Call us at 248-282-3640 or complete the form and our team will reach out soon to help determine your eligibility.

Trial Interest Form

Locations

MHP Rochester - Oakland Medical Group

633 E South Blvd
Suite 1100
Rochester Hills, Michigan