Heart Failure – AT861-G-22-002

This study will evaluate the efficacy, safety, tolerability and pharmacokinetics of JTT-861 administered once daily for 12 weeks in subjects with heart failure with reduced ejection fraction (HFrEF) who are on a stable, guideline-directed medical therapy for heart failure.

Inclusion Criteria:

• Has a clinical diagnosis of symptomatic heart failure (HF) ≥90 days prior to the Screening Visit;
• Is in New York Heart Association (NYHA) functional class II or III at the Screening Visit;
• Is on stable, guideline-directed therapy for HF, consistent with American Heart Association (AHA), American College of Cardiology (ACC), Heart Failure Society of America (HFSA) or European Society of Cardiology (ESC) guidelines for ≥4 weeks prior to the Screening Visit (with at least half of maximal labeled dose of renin-angiotensin-aldosterone system (RAAS) inhibitors and β-blockers, if tolerated)
• Other criteria may apply

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